Research Scientist, Genomics

• We are looking for a highly motivated candidate for the role of a functional genomics lab technician to join the functional genomics team.
• The successful candidate will be responsible for supporting all lab activities from consumable management to assisting with assay development and optimization of high throughput gene-editing workflows.
• In this role, the candidate will work within a matrix, collaborative, fast-paced, team environment across a diverse biotherapeutic portfolio within the company.

Job Responsibilities

• Provide basic laboratory support and coordinate with necessary services on-site to drive efficiencies and maximize value to the customer.
• Laboratory support activities may include local consumable restocking, balance and/or pH meter checks, and other laboratory maintenance activities.
• Maintaining mammalian cell cultures: basic refeeding, splitting, and harvesting activities. Assisting with the plating of cells.
• Support the development of target relevant cell-based assays; optimize, validate, and troubleshoot screening assay robustness, sensitivity, reproducibility; convert assays into HT screening format.
• Assisting with the optimization and utilization of gene editing technologies (CRISPR, RNAi) to develop in vitro functional models, and provide support for high-throughput screening.
• Ensure all tasks and responsibilities are performed according to industry-leading scientific and ethical standards and accurately documented in lab electronic notebook system

Basic Qualifications:

• B.S. in pharmacology, cell biology or biochemistry
• 5+ years of industry research experience with the ability to succeed in a collaborative, matrix environment.
• Experience in RNAi/CRISPR gene editing using various methods such as electroporation, lipid transfection, lentivirus infections.
• Expertise in developing protocols and utilization of liquid handling platforms such as the Hamilton STAR and Labcyte Echo as well as plate readers like BMG Pherastar.

Preferred Qualifications:

• Experience with standard in vitro biochemical and cell-based assays (e.g. reporter gene, protein translocation, HTRF, ELISA etc.), including assay transfer, execution and troubleshooting.
• Experience in molecular biology techniques, including but not limit to qPCR and Western Blot.
• Computational skills enabling automated data acquisition and analysis, and familiarity with related data analysis applications, example Spotfire and PRISM.

Physical Demands

• The overall physical exertion of this position may require:
• Sit or stand 2-3 hours in laboratory areas.
• Walk 2-3 hours within a facility.
• Reach above/below the shoulder, bend at the knees and waist.
• Lift up to 25 lbs.
• Office work activities, including keyboard, with fingers/hands/arms up to 4 hours.
• Work around moving laboratory equipment and machinery.
• Use of personal protective equipment in laboratory.
• Work with biohazards such as blood borne pathogens.

Working Environment

• Must be able to work in a laboratory, controlled environments requiring personal protective     equipment.
• Job pace may be fast and job completion demands may be high.
• Employee may be required to manage hazardous wastes in compliance with company procedures & State/Federal/Local hazardous waste regulations. Duties may include: Identifying, handling, generating, accumulating, storing, labeling.
• Ensure safety, security, and the environment in all aspect of the daily activities, and any potential safety hazards are addressed and corrected immediately.
• Understand ergonomic relationship between people, equipment and working environment.

Women and Minorities are encouraged to apply.